The Scripps Research Institute (TSRI) is a biomedical research corporation established in La Jolla, California with another site in Jupiter, Florida. Its origins stem from a large endowment from Ellen Browning Scripps in the 1920s originally targeted for research on immune disorders. In the 1990s the combined Scripps Clinic and Research Institute became separate entitities. Today, TSRI is one of the most prolific and active research institutes in the United States with a wide range of human disorders/conditions in its focus. Namely, cancer biology, cell therapy, genetics, molecular and experimental medicine, neurobiology and more. The newly constructed Scripps Florida focuses on drug discoveries, basic biomedical research and technologies.
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Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today. They know that ...
Biochemistry
Feb 29, 2024
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Molecules often have a structural asymmetry called chirality, which means they can appear in alternative, mirror-image versions akin to the left and right versions of human hands. One of the great mysteries about the origins ...
Biochemistry
Feb 28, 2024
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60
Scripps Research scientists have developed an antibody that can block the effects of lethal toxins in the venoms of a wide variety of snakes found throughout Africa, Asia and Australia.
Plants & Animals
Feb 21, 2024
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1658
Identifying new ways to target proteins involved in human diseases is a priority for many researchers around the world. However, discovering how to alter the function of these proteins can be difficult, especially in live ...
Biochemistry
Jan 2, 2024
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77
Picrotoxinin, a plant-derived toxin that Asian fishermen traditionally have used to paralyze and catch fish, has long been seen as a possible starting point for new human therapeutics and other neuroactive products.
Biochemistry
Dec 21, 2023
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3
Existing flu vaccines provide only limited, seasonal protection because they target highly changeable proteins on the virus. Scripps Research scientists have now designed a vaccine that should work broadly against influenza ...
Bio & Medicine
Dec 8, 2023
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51
Searching for new ways to block the growth of cancer cells is like looking for a needle in a haystack. Tumor cells rely on thousands of proteins to function, but only a few of those proteins can be precisely targeted by drugs ...
Biochemistry
Oct 5, 2023
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76
Scripps Research chemists have extended a powerful molecule-building method—called C-H activation—to the broad class of chemicals known as alcohols.
Biochemistry
Sep 6, 2023
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130
The ability to sense mechanical stimuli, like touch or blood pressure, is essential to physiological processes in humans and across the animal kingdom. In a new study, Scripps Research scientists show how the sensory ion ...
Cell & Microbiology
Aug 16, 2023
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497
Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health. Mitochondrial stress is associated ...
Molecular & Computational biology
Aug 7, 2023
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106
