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C. difficile, emerging pathogens, genomics, and antimicrobial resistance

C. difficile, emerging pathogens, genomics, and antimicrobial resistance
Biochemical characterization. (a) Starch hydrolysis assay for CB MALS002, CD MALS003, and CT MALS001. Clear zones indicate ability of bacteria to hydrolyze starch. “±” indicates presence and absence of clear zones, respectively. (b) Motility test for CB MALS002, CD MALS003, and CT MALS001. Spreading phenotype was visually assessed to determine degree of motility. Diffuse spreading phenotype from the line of stab inoculum was considered visual confirmation of swimming motility. Experiments were performed in triplicates. CB, Clostridium butyricum; CD, Clostridioides difficile; CT, Clostridium tertium. Credit: OMICS: A Journal of Integrative Biology (2023). DOI: 10.1089/omi.2023.0034

A new study published in OMICS: A Journal of Integrative Biology has identified genes for virulence and antimicrobial resistance in two bacteria that co-occur with C. difficile, suggesting these pathogens as emerging potential threats in planetary health.

Thokur Sreepathy Murali, Ph.D., Ankit Singh Tanwar, Padival Shruptha and colleagues from Manipal Academy of Higher Education, India, and co-author Angela Brand, MD, Ph.D., MPH from Maastricht University, The Netherlands, performed comparative genome analyses of three Clostridia species, C. difficile, C. butyricum, and C. tertium.

C. difficile can cause diarrhea, colitis, sepsis and multiple organ dysfunction. C. butyricum and C. tertium, which reside in the gut, can harbor toxin/virulence genes, and thus, could pose a threat to human health.

Studies such as this one "will further improve our understanding of development of , provide new avenues in genomic monitoring of emerging and offer better treatment strategies for crippling infectious diseases," state the investigators.

"The study provides a timely application of comparative genomics in planetary health and opens up new avenues for diagnostics and therapeutics innovation. The findings unpack the potential threats and interactions of three Clostridia species. I welcome new manuscripts on multi-omics applications in planetary health for peer-review in the journal," says Vural Özdemir, MD, Ph.D., DABCP, Editor-in-Chief of OMICS.

More information: Ankit Singh Tanwar et al, Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species, OMICS: A Journal of Integrative Biology (2023). DOI: 10.1089/omi.2023.0034

Citation: C. difficile, emerging pathogens, genomics, and antimicrobial resistance (2023, May 25) retrieved 7 March 2024 from https://phys.org/news/2023-05-difficile-emerging-pathogens-genomics-antimicrobial.html
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